sickle cell anaemia

A severe hereditary form of anaemia, mainly affecting people of African origin, in which mutated haemoglobin distorts red blood cells into a crescent shape, causing the cells to become stuck in capillaries. Downstream tissues are thus deprived of oxygen causing ischaemia and infarction.
Syn: drepanocytosis, sickle-cell disease

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  • sickle-cell anaemia — noun a congenital form of anemia occurring mostly in blacks; characterized by abnormal blood cells having a crescent shape • Syn: ↑sickle cell anemia, ↑sickle cell disease, ↑crescent cell anemia, ↑crescent cell anaemia, ↑drepanocytic anemia,… …   Useful english dictionary

  • sickle-cell anaemia — N UNCOUNT Sickle cell anaemia is an inherited illness in which the red blood cells become curved, causing a number of health problems. (in AM, use sickle cell anemia) …   English dictionary

  • sickle-cell anaemia — sickle cell a naemia BrE sickle cell anemia AmE n [U] a serious illness that mainly affects black people, in which the blood cells change shape, causing weakness and fever …   Dictionary of contemporary English

  • sickle-cell anaemia — (also sickle cell disease) noun a severe hereditary form of anaemia in which a mutated form of haemoglobin distorts the red blood cells into a crescent shape at low oxygen levels …   English new terms dictionary

  • sickle-cell anaemia — noun A disease characterized by sickle shaped red blood cells. Syn: sickle cell disease …   Wiktionary

  • sickle-cell anaemia — BrE, sickle cell anemia AmE noun (U) a serious illness that mainly affects black people, in which the blood cells change shape, causing weakness and fever …   Longman dictionary of contemporary English

  • sickle cell anaemia — Disease common in races of people from areas in which malaria is endemic. The cause is a point mutation in haemoglobin (valine instead of glutamic acid at position 6), and the altered haemoglobin (HbS) crystallises readily at low oxygen tension.… …   Dictionary of molecular biology

  • sickle-cell anaemia — /ˌsɪkəl sɛl əˈnimiə/ (say .sikuhl sel uh neemeeuh) noun a hereditary disease characterised by the crystallisation of sickle cells within erythrocytes, distorting them and clogging blood vessels …   Australian English dictionary

  • sickle-cell anaemia — UK / US noun [uncountable] a blood disease that mainly affects black people …   English dictionary

  • sickle-celled anaemia — sickle cell anaemia or sickle celled anaemia noun (also called sickleˈmia) a severe hereditary anaemia, mainly affecting black people, in which the red blood cells become distorted into a sickle shape and are subsequently destroyed by the body s… …   Useful english dictionary

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