Either of a pair of related thiol-dependent enzymes: glyoxalase І, which catalyses the isomerisation of the spontaneously formed hemithioacetal adduct between GSH and 2-oxoaldehydes (such as methylglyoxal) into S-2-hydroxyacylglutathione; and glyoxalase ІІ, which hydrolyses these thiolesters.

Wikipedia foundation.

Look at other dictionaries:

  • glyoxalase — An enzyme, lactoylglutathione lyase (g. I) or hydroxyacylglutathione hydrolase (g. II), in red cells and other tissues that converts glyoxal and substituted glyoxals bound to glutathione into the corresponding free hydroxy acid s (g. II) or… …   Medical dictionary

  • glyoxalase — gly·ox·a·lase …   English syllables

  • glyoxalase — glīˈäksəˌlās, āz noun ( s) Etymology: glyoxal + ase : an enzyme that accelerates reversibly the conversion in the presence of glutathione of pyruvaldehyde to lactic acid …   Useful english dictionary

  • Glyoxalase system — The glyoxalase system is a set of enzymes that carry out the detoxification of methylglyoxal and the other reactive aldehydes that are produced as a normal part of metabolism. [Vander Jagt, D. (1989). The glyoxalase system . In Glutathione:… …   Wikipedia

  • Système glyoxalase — Le système glyoxalase est une série d enzymes prenant en charge la détoxification du méthylglyoxal et d autres espèces réactives d aldéhydes produites pendant les différentes étapes du métabolisme[1]. Ce système a déjà été étudié chez les… …   Wikipédia en Français

  • GLO1 — Glyoxalase I, also known as GLO1, is a human gene.cite web | title = Entrez Gene: GLO1 glyoxalase I| url = Cmd=ShowDetailView TermToSearch=2739| accessdate = ] It is a Lactoylglutathione lyase. PBB …   Wikipedia

  • lactoylglutathione lyase — Glyoxalase I; a lyase cleaving S d lactoylglutathione to glutathione and methylglyoxal. SYN: aldoketomutase, ketone aldehyde mutase, methylglyoxalase. * * * lac·to·yl·glu·ta·thi·one ly·ase (lak″to əl gloo″tə thiґōn… …   Medical dictionary

  • GLO I — (glyoxalase I)    A protein marker found in the blood and other body fluids …   Forensic science glossary

  • Lactoylglutathione lyase — Identifiers EC number CAS number 9033 12 9 …   Wikipedia

  • HAGH — Hydroxyacylglutathione hydrolase, also known as HAGH, is a human gene.cite web | title = Entrez Gene: HAGH hydroxyacylglutathione hydrolase| url = Cmd=ShowDetailView TermToSearch=3029| accessdate …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.